Norfolk and Suffolk NHS Foundation Trust
Pharmacy, Hellesdon Hospital, Norwich, NR6 5BE
http://www.nsft.nhs.uk/

Professor Stephen Bazire
01603-421452
steve.bazire@nsft.nhs.uk

How do medicines work in the brain?

In order to try to understand a little about how medicines work in the brain, it is best to first learn a bit about the brain.

Each human being has one head and one brain (NB Zaphod Beeblebrox wasn't human)

The brain has a very complex structure about which, in all honesty, we know very little.
As someone once said "if the brain were simple enough for us to understand it, then we'd be too simple to understand it" (it's worth working that one out!)

Each brain has somewhere around 100,000,000,000 brain cells (also called neurons).
It also has about 1000,000,000,000 glial cells (these are the support cells that keep neurons cells ticking over).

Each brain cell connects with other brain cells by means of nerve fibres (the wiring connecting brain cells together). There are about 4 million miles of nerve fibres in each brain. Some fibres may have up to 10,000 branches in them.

Brain cells have lots of connections with other cells, up to around 10,000 each! The junctions at the end of the neurons are called synapses. There are probably around 150,000,000,000,000 synapses in a healthy adult brain.

As you can see, overall the brain is a most extraordinary and complex part of the body. It is surrounded by a membrane (the ‘blood-brain barrier’) that controls very carefully what gets into and out of the brain. 

Updated 11.11

Main pharmacy contact points

Main Trust switchboard in Norwich, tel: 01603-421421
Dispensary and all enquiries, tel: 01603-421212, fax: 01603-421365
Pharmacy office tel: 01603-421319
Medicines Information tel: 01603-421212
Unthank Road pharmacy tel: 01603-750031
Deputy Director and Clinical Pharmacy Manager John Hunter, tel: 01603-421364

Opening hours:
Main pharmacy open Monday to Friday: 8.30-16.30 (open at 9.15 on Wednesdays for staff meeting)
Unthank Road pharmacy tel: 01603-671917 open 9.15-12.00 Monday to Friday, also Tuesday and Wednesday afternoons for dose assessments.

Service objectives:
The pharmacy service to Norfolk and Suffolk NHS Foundation Trust has five main aims:

  1. Efficient drug distribution and purchasing
  2. Provision of accurate and independent education and information about medicine therapy to service users and carers
  3. Information and education for Trust and other professionals, and voluntary helpers
  4. Clinical activities to help ensure the optimum use of drug therapies
  5. Medicine management to ensure the most cost-effective use is made of resources